I couldn't find specific information regarding the most difficult ages for people born in the Year of the Snake in 1965. The search results provide information for those born in 1977.

However， based on the search results about people born in the Year of the Snake， challenging times often occur around these ages:

13 years old During puberty， children may be rebellious and parents may have difficulties communicating with them.

27 years old Career and personal life challenges may cause anxiety.

36 years old There may be career and marriage challenges， such as betrayal or partnership problems that lead to financial issues. Marital problems may arise due to the inability to handle debt together.

45 years old Financial crises can arise.

55 years old Health and marital issues can cause significant problems.

60 years old Health issues can arise.

77 years old Physical and emotional challenges can arise， along with feelings of loneliness.